MicroBiome Restore Probiotic — Complete 2025 Guide to Ingredients, Benefits and Gut Results
Introduction
Gut health has become one of the most researched areas of modern medicine, with mounting evidence linking the gut microbiome to everything from digestive comfort to immune function, mental clarity, and chronic disease prevention. Yet despite this awareness, millions of Americans struggle with recurring digestive symptoms—bloating, irregular bowel movements, food sensitivities, and IBS—often cycling through probiotic supplements that promise relief but deliver disappointing results.
The problem isn't that probiotics don't work. The problem is that most probiotic formulations are designed for manufacturing convenience rather than clinical efficacy. They're filled with cheap bulking agents like microcrystalline cellulose (MCC), magnesium stearate, and silica—substances that take up valuable capsule space, may interfere with probiotic viability, and can irritate the very gut environment they're meant to heal. Research suggests these fillers can reduce the effectiveness of beneficial bacteria by coating probiotic cells and creating barriers to absorption[1].
MicroBiome Restore® was formulated to challenge this industry standard. Created by scientists with backgrounds in neuroscience and microbiology, this comprehensive probiotic formula combines 26 diverse probiotic strains—including resilient soil-based organisms—with 7 certified organic prebiotics and 80+ trace minerals from sea vegetables. Every ingredient serves a biological purpose. There are no fillers, no flow agents, no synthetic polymers. Just pure, potent support for gut restoration.
The results speak for themselves: customers most commonly report noticeable changes within 3-7 days, with significant improvements in bloating, regularity, and digestive comfort within the first two weeks. For those dealing with IBS, SIBO, or chronic gut imbalances, MicroBiome Restore offers a science-backed approach to rebuilding a thriving gut microbiome from the ground up.
This guide provides a complete analysis of MicroBiome Restore's formulation, breaking down each ingredient with scholarly research, explaining how multi-strain probiotics outperform single-strain alternatives, and outlining realistic expectations for gut health improvements. Whether you're new to probiotics or frustrated with products that haven't delivered, this is your roadmap to understanding what actually works—and why.
Table of Contents
- What Makes MicroBiome Restore Different
- Benefits by Use Case: How MicroBiome Restore Addresses Specific Gut Health Concerns
- Complete Ingredient Breakdown: The Science Behind Each Component
- The Anti-Filler Philosophy: Why Purity Matters
- Usage Protocol & Optimization: How to Get the Best Results
- Quality Assurance & Manufacturing Standards
- Frequently Asked Questions
- Conclusion: Invest in Your Gut Health with Confidence
- References
What Makes MicroBiome Restore Different
The Multi-Strain Advantage
Most probiotic supplements contain 1-3 strains, typically Lactobacillus acidophilus or Bifidobacterium lactis. While these are beneficial bacteria, the human gut microbiome contains hundreds of species working in complex, interconnected ways. A healthy microbiome requires diversity—different strains colonize different regions of the digestive tract, perform distinct metabolic functions, and produce various beneficial compounds[2].
MicroBiome Restore contains 26 probiotic strains delivering a guaranteed minimum of 15 billion CFU per serving. This includes:
- 21 traditional probiotic strains from genera including Lactobacillus, Bifidobacterium, Streptococcus, Enterococcus, Lactococcus, and Pediococcus
- 5 soil-based organisms (SBOs) from the Bacillus genus, known for exceptional survivability and colonization
This isn't arbitrary diversity—each strain family serves specific functions. Research comparing single-strain and multi-strain probiotics consistently shows that diverse formulations provide more comprehensive symptom relief, particularly for IBS and functional digestive disorders[3].
Soil-Based Organisms: The Resilient Colonizers
One of the most significant differentiators in MicroBiome Restore is the inclusion of soil-based probiotic organisms. These spore-forming bacteria—including Bacillus coagulans, Bacillus subtilis, Bacillus clausii, Bacillus licheniformis, and Bacillus pumilus—evolved to survive harsh environmental conditions.
Unlike many traditional probiotics that can be degraded by stomach acid and bile, SBOs form protective spores that remain dormant through the acidic stomach environment, then activate in the alkaline conditions of the intestines where they're needed most[4]. This remarkable survival capability means a higher percentage of these organisms reach your gut alive and ready to colonize.
Clinical studies have shown that Bacillus species can help restore gut balance after antibiotic use, improve symptoms in IBS patients, and enhance the diversity of the overall microbiome[5]. Their spore-forming nature also makes them naturally shelf-stable without refrigeration—a practical advantage that traditional probiotics often can't match without complex stabilization techniques.
Comprehensive Prebiotic Support
Probiotics are only half the equation. Without proper nutrition, even the best bacterial strains struggle to establish themselves in your gut. This is where prebiotics become critical—they're specialized plant fibers and compounds that selectively feed beneficial bacteria, helping them multiply and outcompete harmful organisms.
MicroBiome Restore includes 7 certified organic prebiotics totaling 1,470 mg per serving:
- Maitake Mushroom (115 mg): Rich in beta-glucans and polysaccharides that stimulate Lactobacillus and Bifidobacterium growth while providing immune-modulating benefits[6]
- Norwegian Kelp (125 mg): Provides alginate fiber and trace minerals that support Bifidobacterium colonization and gut barrier function[7]
- Bladderwrack (125 mg): Contains fucoidan, a prebiotic fiber that promotes beneficial bacteria and reduces inflammation[8]
- Oarweed (125 mg): High in alginates and laminarin that support gut bacteria and intestinal healing[9]
- Fig Fruit (150 mg): Delivers soluble and insoluble fiber with antioxidants that calm intestinal inflammation[10]
- Jerusalem Artichoke (150 mg): One of nature's richest sources of inulin, a prebiotic fiber extensively studied for promoting Bifidobacterium growth and short-chain fatty acid production[11]
- Acacia Gum (200 mg): Soluble fiber that feeds beneficial bacteria while being remarkably gentle on sensitive stomachs, making it ideal for IBS sufferers[12]
The formula also includes non-GMO rice maltodextrin (160 mg) and non-GMO tapioca maltodextrin (320 mg) as substrates. These serve as protective matrices during freeze-drying, keeping probiotics viable without refrigeration while providing an initial energy source when the bacteria activate in your gut.
Together, these sea vegetables provide over 80 trace minerals—essential micronutrients that bacteria require for metabolism and reproduction. This is a critical detail most probiotic manufacturers overlook: bacterial cells need minerals just like human cells do. Without adequate mineral support, probiotics may struggle to establish themselves even in an otherwise favorable environment.
The Clean Label Commitment
What's not in MicroBiome Restore is just as important as what is. The supplement industry has normalized the use of cheap fillers and flow agents that make manufacturing easier but may compromise effectiveness. Common culprits include:
- Microcrystalline cellulose (MCC): Processed wood pulp used as a bulking agent. Research suggests MCC may disrupt gut microbiota and cause digestive discomfort in sensitive individuals[13]
- Magnesium stearate: A lubricant that facilitates tablet compression but can form a hydrophobic coating around probiotic cells, potentially reducing their absorption and viability[14]
- Silicon dioxide: An anti-caking agent that may interfere with beneficial bacteria and immune cell function[15]
- HPMC (hypromellose): A semi-synthetic polymer commonly used in capsules that doesn't break down into beneficial compounds
MicroBiome Restore contains none of these substances. Instead, it uses fermented pullulan capsules—plant-based capsules derived from tapioca that break down in the large intestine into short-chain fatty acids, providing additional prebiotic benefit. This innovative capsule technology means even the delivery system supports your gut health.
Every milligram of MicroBiome Restore serves a biological purpose. There are no flow agents, no manufacturing lubricants, no synthetic polymers taking up space that could be used for beneficial bacteria and prebiotics. This makes the manufacturing process more challenging and expensive, but it ensures maximum efficacy in every dose.
Shelf-Stable Without Compromise
Many people assume probiotics need refrigeration to remain viable. This was true for early-generation probiotics using fragile bacterial strains, but modern formulation science has changed the game. MicroBiome Restore is fully shelf-stable at room temperature while maintaining its guaranteed 15 billion CFU through the expiration date—not just at manufacture.
This stability comes from three factors: the natural resilience of soil-based organisms, careful selection of robust traditional probiotic strains, and the protective maltodextrin matrix used during freeze-drying. The result is a probiotic you can keep in your purse, take while traveling, or store in your medicine cabinet without worrying about potency loss.
Benefits by Use Case: How MicroBiome Restore Addresses Specific Gut Health Concerns
The power of a multi-strain, prebiotic-enhanced probiotic lies in its ability to address multiple aspects of gut dysfunction simultaneously. Let's explore how MicroBiome Restore supports specific digestive concerns backed by scientific research.
Bloating Relief & Digestive Comfort
Bloating affects up to 30% of the general population and is one of the most frustrating digestive complaints[16]. It typically results from excessive gas production caused by microbial imbalance (dysbiosis), where harmful bacteria ferment undigested food into hydrogen, methane, and carbon dioxide gases.
MicroBiome Restore addresses bloating through multiple mechanisms:
Lactobacillus plantarum is one of the most well-researched species for bloating relief. In a landmark double-blind study of 214 IBS patients, L. plantarum supplementation resulted in a 51.9% reduction in abdominal pain frequency, with 78% of participants reporting excellent or good symptom relief including reduced bloating[17]. This strain produces lactic acid that creates an acidic environment inhospitable to gas-producing bacteria while also demonstrating anti-inflammatory effects.
Bifidobacterium lactis has shown particular effectiveness for bloating related to constipation and slow gut motility. A clinical trial found that combining B. lactis with L. acidophilus significantly improved bloating severity at both 4 weeks (p=0.009) and 8 weeks (p<0.01) compared to placebo[18]. This species helps normalize intestinal transit time, preventing the stagnation that leads to fermentation and gas.
Bacillus species (the soil-based organisms in the formula) have demonstrated ability to reduce Methanobrevibacter, a gas-producing archaeon directly linked to bloating and methane-predominant SIBO[19]. By competing with these gas producers, SBOs help rebalance the microbiome toward less fermentative metabolism.
The comprehensive prebiotic blend supports these mechanisms by providing selective nutrition for beneficial bacteria while starving harmful organisms. Acacia fiber, in particular, is gentle enough for sensitive stomachs while still promoting beneficial bacterial growth and short-chain fatty acid production[20].
Most customers report noticeable reductions in bloating within the first week, with continued improvement over 2-4 weeks as the microbiome rebalances.
Sensitive Gut & IBS Support
Irritable bowel syndrome affects 10-15% of the population and is characterized by abdominal pain, bloating, and altered bowel habits without detectable structural abnormalities[21]. Research consistently shows that people with IBS have altered gut microbiota compositions with reduced diversity and increased populations of pro-inflammatory bacteria.
Multiple probiotic strains in MicroBiome Restore have specific evidence for IBS symptom relief:
Bifidobacterium infantis has demonstrated remarkable efficacy for IBS in clinical trials. A dose-ranging study of 362 women with IBS found that B. infantis significantly reduced abdominal pain, bloating, bowel dysfunction, and incomplete evacuation[22]. This species appears to work by normalizing pro-inflammatory cytokine ratios, helping to calm the chronic low-grade inflammation characteristic of IBS.
Lactobacillus acidophilus has shown ability to modulate pain-associated receptors in the gastrointestinal tract, including μ-opioid and cannabinoid receptors[23]. This helps explain its effectiveness for visceral hypersensitivity—the heightened pain perception common in IBS patients. In a multi-center trial of 330 IBS patients, L. acidophilus supplementation resulted in 52.3% experiencing clinically significant improvement in abdominal pain severity[24].
Bifidobacterium longum has demonstrated benefits for both digestive symptoms and the anxiety/depression often comorbid with IBS through its effects on the gut-brain axis[25]. This species helps produce neurotransmitter precursors and modulates inflammatory signaling that affects mood and stress response.
The World Gastroenterology Organisation recognizes specific Lactobacillus and Bifidobacterium species—many of which are included in MicroBiome Restore—as having Level 2 evidence (strong clinical support) for IBS symptom management[26].
For those with IBS, customers commonly report improvements in bowel regularity, reduced urgency, decreased abdominal discomfort, and better tolerance to previously problematic foods within 2-4 weeks of consistent use.
Immune & Whole-Body Wellness
Approximately 70-80% of the immune system resides in the gut-associated lymphoid tissue (GALT)[27]. The gut microbiome plays a central role in training immune cells, producing antimicrobial compounds, and regulating inflammatory responses throughout the body.
MicroBiome Restore supports immune function through several pathways:
Probiotic strains stimulate immune cell activity: Lactobacillus and Bifidobacterium species have been shown to enhance natural killer (NK) cell activity, increase secretory IgA production in the gut, and promote balanced T-helper cell responses[28]. This helps your immune system respond appropriately to threats without overreacting to harmless substances.
Soil-based organisms strengthen gut barrier function: Bacillus species produce antimicrobial peptides and support tight junction integrity between intestinal cells, reducing intestinal permeability ("leaky gut") that can trigger systemic inflammation[29].
Beta-glucans from Maitake mushroom act as immunomodulators, enhancing immune surveillance while preventing excessive inflammatory responses[30]. These compounds interact with immune receptors in the gut, helping to calibrate immune function.
Trace minerals from sea vegetables support immune enzyme function. Minerals like zinc, selenium, and iodine from kelp species are essential cofactors for immune signaling and antioxidant defense systems[31].
Beyond direct immune benefits, many customers report increased energy levels, improved skin clarity, and better resistance to seasonal illnesses—secondary benefits that reflect the fundamental role of gut health in overall wellness.
Post-Antibiotic Recovery & Microbiome Restoration
Antibiotics are lifesaving medications, but they're non-selective—they kill beneficial bacteria along with pathogens. A single course of broad-spectrum antibiotics can reduce gut microbial diversity for months or even years[32], potentially leading to antibiotic-associated diarrhea, C. difficile overgrowth, and long-term dysbiosis.
MicroBiome Restore is particularly well-suited for post-antibiotic recovery:
Soil-based organisms are inherently antibiotic-resistant due to their spore-forming nature, meaning they can be taken during antibiotic therapy without being destroyed. Bacillus clausii, in particular, has been extensively studied for preventing antibiotic-associated diarrhea and reducing dysbiosis[33].
Multi-strain diversity accelerates microbiome recovery: Research shows that diverse probiotic formulations are more effective than single strains for restoring microbial richness after antibiotic disruption[34]. The 26 strains in MicroBiome Restore provide a broad spectrum of beneficial bacteria to help fill ecological niches left vacant by antibiotic treatment.
Prebiotic support promotes colonization: The comprehensive prebiotic blend provides the nutritional substrate necessary for reintroduced bacteria to establish themselves and multiply, accelerating the recovery process.
For antibiotic users, taking MicroBiome Restore during and after treatment may help maintain gut health and prevent common post-antibiotic complications like diarrhea, yeast overgrowth, and prolonged digestive dysfunction.
Long-Term Gut Microbiome Balance
Even for those without specific digestive complaints, maintaining a diverse, balanced gut microbiome is one of the most important foundations of long-term health. Research links gut microbiome composition to metabolic health, cardiovascular function, cognitive performance, mood regulation, and healthy aging[35].
Modern life presents numerous challenges to gut health:
- Dietary factors: Processed foods, added sugars, and insufficient fiber deprive beneficial bacteria of nutrition while feeding harmful organisms
- Environmental toxins: Pesticides, artificial additives, and chlorinated water can disrupt microbial balance
- Stress: Chronic psychological stress alters gut motility, secretion, and permeability, favoring dysbiotic shifts[36]
- Reduced microbial exposure: Modern sanitation, while preventing infectious disease, may have eliminated beneficial environmental bacteria that historically colonized the human gut
Regular probiotic supplementation with a diverse, high-quality formula like MicroBiome Restore acts as "microbiome insurance"—helping to maintain the bacterial diversity and balance that supports optimal health even in the face of these modern challenges.
Many customers use MicroBiome Restore as a daily maintenance supplement, reporting consistent digestive comfort, regular bowel movements, sustained energy levels, and overall wellness that reflects optimal gut function.
Complete Ingredient Breakdown: The Science Behind Each Component
Understanding exactly what you're putting in your body—and why—is essential for making informed supplement choices. Let's examine each ingredient in MicroBiome Restore with the scientific evidence supporting its inclusion.
The 26 Probiotic Strains: Diverse Functions for Comprehensive Support
MicroBiome Restore's 26 strains can be organized by genus and their primary benefits, though it's important to note that many strains provide multiple overlapping benefits:
Bifidobacterium Species (5 strains)
Bifidobacterium bifidum: Predominant in the large intestine, particularly important for maintaining gut barrier integrity and producing antimicrobial compounds. Research shows B. bifidum helps alleviate IBS symptoms and supports healthy immune responses[37].
Bifidobacterium breve: One of the most abundant species in infant gut microbiomes, B. breve helps ferment dietary fiber into short-chain fatty acids (particularly acetate) and has demonstrated anti-inflammatory properties. Studies show benefits for constipation and celiac disease symptoms[38].
Bifidobacterium infantis: As discussed earlier, this species has remarkable efficacy for IBS, particularly for reducing abdominal pain and normalizing bowel function. It produces high levels of anti-inflammatory cytokines[39].
Bifidobacterium lactis (B. animalis subsp. lactis): Exceptionally resilient strain that survives stomach acid well. Clinical trials show B. lactis improves intestinal motility, reduces bloating, and enhances immune function. It's particularly effective for constipation-predominant IBS[40].
Bifidobacterium longum subsp. longum: One of the first bacterial species to colonize the infant gut, B. longum persists throughout life. It produces lactic and acetic acids, helps metabolize dietary fiber, and has demonstrated benefits for both digestive symptoms and mental health through gut-brain axis modulation[41].
Lactobacillus Species (11 strains)
Lactobacillus acidophilus: Perhaps the most well-known probiotic species, L. acidophilus colonizes the small intestine and vaginal tract. It produces lactic acid, hydrogen peroxide, and bacteriocins that inhibit pathogenic bacteria. Research supports its use for digestive health, lactose intolerance, and vaginal health[42].
Lactobacillus buchneri: Produces high levels of lactic acid and is particularly stable during storage. While less studied than other Lactobacillus species, L. buchneri contributes to gut acidification that discourages harmful bacteria.
Lactobacillus casei: Survives passage through the stomach well and can adhere to intestinal cells. L. casei has been shown to enhance immune function, reduce diarrhea duration, and support overall gut health[43].
Lactobacillus delbrueckii subsp. bulgaricus: Traditionally used in yogurt fermentation, this species aids lactose digestion and produces antimicrobial compounds. While it may not colonize permanently, it provides benefits during transit through the gut[44].
Lactobacillus fermentum: Produces both lactic acid and antioxidant compounds. Research suggests L. fermentum may help reduce cholesterol levels and support immune function[45].
Lactobacillus gasseri: Unique among Lactobacillus species for its potential metabolic benefits. Studies have shown L. gasseri may help reduce abdominal fat and support healthy weight management, in addition to standard probiotic benefits[46].
Lactobacillus paracasei: Closely related to L. casei, this species has demonstrated immune-enhancing properties and may help reduce allergic responses. It's particularly stable and survives well in harsh conditions[47].
Lactobacillus plantarum: One of the most versatile and well-researched probiotic species. L. plantarum naturally occurs in fermented foods like sauerkraut and has exceptional ability to survive stomach acid. As discussed earlier, it has strong clinical evidence for reducing IBS symptoms, particularly bloating and abdominal pain[48].
Lactobacillus reuteri: Produces the antimicrobial compound reuterin, which inhibits pathogenic bacteria and yeast. L. reuteri has unique immunomodulatory properties and has been studied for benefits ranging from infant colic to oral health[49].
Lactobacillus rhamnosus: One of the most extensively researched probiotic species globally. L. rhamnosus GG (the most studied strain) has demonstrated benefits for preventing and treating diarrhea, supporting immune function, and reducing eczema risk in infants[50]. The species as a whole shows excellent adhesion to intestinal cells and survival rates.
Lactobacillus salivarius: Found naturally in the mouth and small intestine, L. salivarius produces antimicrobial compounds and may help prevent oral and digestive infections. Research suggests benefits for inflammatory bowel conditions[51].
Additional Beneficial Genera (5 strains)
Enterococcus faecium: While some Enterococcus species can be pathogenic, E. faecium probiotic strains produce bacteriocins that inhibit harmful bacteria and support gut barrier function. Research shows efficacy for restoring gut balance after antibiotic use[52].
Lactococcus lactis subsp. lactis: Commonly used in dairy fermentation, this species produces lactic acid and helps with lactose digestion. It contributes to maintaining proper intestinal pH[53].
Pediococcus acidilactici: Produces antimicrobial compounds and contributes to gut balance. While less studied than other genera, Pediococcus species have shown potential for supporting digestive health and inhibiting pathogens[54].
Pediococcus pentosaceus: Similar benefits to P. acidilactici, this species contributes to lactic acid production and microbial balance.
Streptococcus thermophilus: Widely used in yogurt production, S. thermophilus aids lactose digestion and may help reduce symptoms of lactose intolerance. It produces lactic acid and supports gut barrier function[55].
Soil-Based Organisms - Bacillus Species (5 strains)
The inclusion of soil-based organisms represents a significant advancement in probiotic science. These spore-forming bacteria provide benefits that traditional probiotics cannot match:
Bacillus coagulans: Perhaps the most well-researched Bacillus probiotic, B. coagulans survives stomach acid as a spore and germinates in the intestines. Clinical trials show benefits for IBS, inflammatory bowel disease, and post-antibiotic recovery[56]. It's remarkably stable and shelf-stable.
Bacillus clausii: Extensively studied in Europe for preventing and treating antibiotic-associated diarrhea. B. clausii spores are inherently resistant to antibiotics, making it ideal for concurrent use during antibiotic therapy[57].
Bacillus licheniformis: Produces proteolytic enzymes that aid protein digestion and antimicrobial compounds that inhibit harmful bacteria. Research suggests benefits for gut barrier function and immune support[58].
Bacillus pumilus: Produces antimicrobial peptides and contributes to microbial diversity. While less studied than other Bacillus species, it adds to the comprehensive approach of multiple SBO strains.
Bacillus subtilis: One of the most resilient probiotic organisms, B. subtilis survives extreme conditions and produces various beneficial compounds including vitamin K2. Studies show it helps restore gut balance, improves digestion, and supports immune function[59].
The 7 Organic Prebiotics: Selective Nutrition for Beneficial Bacteria
While probiotics introduce beneficial bacteria, prebiotics provide the specialized nutrition these organisms need to thrive, multiply, and exert their beneficial effects. MicroBiome Restore's prebiotic blend is carefully formulated to support the diverse bacterial strains in the formula:
Maitake Mushroom (Grifola frondosa) - 115 mg
Maitake, known as the "dancing mushroom," is rich in beta-glucans—complex polysaccharides that function as both prebiotics and immunomodulators. These compounds selectively feed Lactobacillus and Bifidobacterium species while stimulating short-chain fatty acid production[60].
Beyond prebiotic effects, maitake contains immunostimulatory proteoglycans that interact with gut-associated lymphoid tissue, enhancing immune surveillance and response. Research shows maitake can help regulate inflammation, support gut barrier integrity, and contribute to metabolic health[61].
The inclusion of maitake represents a sophisticated approach to gut health—it's not just feeding bacteria, but also supporting the immune function that's intrinsically linked to microbiome balance.
Norwegian Kelp (Ascophyllum nodosum) - 125 mg
Norwegian kelp is a brown seaweed particularly rich in alginate fiber and trace minerals. Alginates are polysaccharides that resist digestion in the upper GI tract, reaching the colon where they serve as prebiotics for beneficial bacteria[62].
Perhaps more importantly, kelp provides a spectrum of trace minerals including iodine, selenium, zinc, iron, and magnesium—micronutrients that bacterial enzymes require for metabolic processes. Modern agriculture has depleted many soils of these minerals, and gut bacteria depend on dietary sources to function optimally.
Research on seaweed-derived prebiotics suggests they improve gut microbiota diversity, reduce pathogenic bacteria, and support gut barrier function through multiple mechanisms[63].
Bladderwrack (Fucus vesiculosus) - 125 mg
Bladderwrack is another brown seaweed rich in fucoidan—a sulfated polysaccharide with prebiotic and anti-inflammatory properties. Fucoidan has been shown to promote beneficial bacteria growth while inhibiting pathogenic species[64].
This sea vegetable also provides iodine and other minerals essential for thyroid function and metabolic health. The anti-inflammatory compounds in bladderwrack may help calm intestinal inflammation, creating a more favorable environment for probiotic colonization[65].
Oarweed (Laminaria digitata) - 125 mg
Oarweed is a large kelp species high in laminarin (a beta-glucan) and alginates. These compounds have demonstrated prebiotic effects, promoting beneficial bacteria while also exhibiting potential to bind and remove unwanted compounds from the digestive tract[66].
The mucilaginous polysaccharides in oarweed may help soothe and protect the intestinal lining, supporting mucosal healing—particularly important for those with IBS or inflammatory digestive conditions.
Fig Fruit (Ficus carica) - 150 mg
Figs are recognized for exceptional fiber content, containing both soluble and insoluble fiber that supports digestive motility and feeds beneficial bacteria. The soluble fiber in figs acts as a prebiotic, while the insoluble fiber helps promote regular bowel movements[67].
Figs also contain antioxidants including polyphenols that help reduce oxidative stress and inflammation in the gut. Research indicates fig fiber can increase short-chain fatty acid production and support Bifidobacterium growth[68].
The gentle, natural laxative effect of figs makes this ingredient particularly valuable for those dealing with constipation-related bloating.
Jerusalem Artichoke (Helianthus tuberosus) - 150 mg
Jerusalem artichoke is one of nature's richest sources of inulin, a well-studied prebiotic fiber that selectively nourishes Bifidobacterium species. Inulin resists digestion in the upper GI tract and reaches the colon intact, where beneficial bacteria ferment it into short-chain fatty acids—particularly butyrate, acetate, and propionate[69].
These short-chain fatty acids provide energy for colonocytes (colon cells), reduce intestinal pH (discouraging pathogenic bacteria), and have anti-inflammatory effects throughout the body. Numerous clinical studies confirm inulin's effectiveness as a prebiotic, demonstrating improvements in gut microbiota diversity, calcium absorption, and bowel regularity[70].
The inulin content in MicroBiome Restore ensures the Bifidobacterium strains have optimal nutrition for colonization and activity.
Acacia Gum (Acacia senegal) - 200 mg
Acacia gum, also known as gum arabic, is a soluble fiber with remarkable gentleness—making it ideal for individuals with sensitive stomachs or IBS. Unlike some prebiotics that can cause initial gas and bloating, acacia gum is fermented slowly in the colon, producing beneficial effects without the discomfort[71].
Clinical studies demonstrate that acacia gum stimulates the growth of Lactobacillus and Bifidobacterium species, promotes short-chain fatty acid production, and has anti-inflammatory properties. Research specifically on IBS patients has shown that acacia supplementation can improve symptoms and normalize bowel function[72].
The 200 mg dose of acacia in MicroBiome Restore provides meaningful prebiotic support while being well-tolerated even by those who struggle with other fiber supplements.
Understanding the Maltodextrin Substrate
MicroBiome Restore contains 160 mg of non-GMO rice maltodextrin and 320 mg of non-GMO tapioca maltodextrin. These ingredients serve as substrates rather than primary prebiotics—they play a specific technical role in maintaining probiotic viability.
During freeze-drying (lyophilization), probiotic bacteria are highly vulnerable to damage. Maltodextrins act as protective matrices, surrounding bacterial cells and preventing structural damage during the drying process and subsequent storage. This protection is essential for maintaining the guaranteed 15 billion CFU through the product's shelf life without requiring refrigeration.
Additionally, when you consume the capsules, maltodextrins provide an immediate energy source that helps probiotics activate and begin metabolizing as they reach your intestines. While not classified as prebiotics in the same way as inulin or beta-glucans, these substrates serve an important functional purpose in probiotic delivery and activation.
The Anti-Filler Philosophy: Why Purity Matters
The supplement industry has normalized the use of various fillers, binders, and flow agents that make manufacturing easier and cheaper but may compromise product effectiveness. Understanding these common additives—and why MicroBiome Restore excludes them—is essential for making informed supplement choices.
The Problem with Microcrystalline Cellulose
Microcrystalline cellulose (MCC) is processed wood pulp used as a filler and binding agent in supplements. While the FDA considers it "generally recognized as safe," MCC presents several concerns particularly relevant to probiotic supplementation:
Space displacement: MCC takes up valuable capsule volume that could be used for beneficial ingredients. In a probiotic supplement, every milligram of MCC means less room for bacterial strains, prebiotics, or supportive nutrients.
Potential gut microbiome disruption: Emerging research suggests MCC may alter gut microbiota composition, potentially working against the very probiotics you're trying to establish[73]. Studies have found that cellulose additives can change bacterial populations in ways that may not support optimal gut health.
Digestive sensitivity: Some individuals report bloating, gas, and digestive discomfort from MCC, particularly those with sensitive stomachs or IBS—precisely the population that needs probiotic support most[74].
For individuals seeking gut health improvement, taking a probiotic filled with MCC creates a counterproductive situation: attempting to improve your microbiome while consuming a substance that may disrupt it.
Magnesium Stearate and Vegetable Stearate Concerns
Magnesium stearate and vegetable stearate are lubricants used to prevent ingredients from sticking to manufacturing equipment during tablet and capsule production. They make the manufacturing process faster and cheaper, but research suggests potential drawbacks:
Biofilm formation: Stearates can form a hydrophobic (water-repelling) coating around capsule contents, potentially slowing dissolution and reducing absorption of active ingredients. For probiotics specifically, this coating could interfere with the bacteria reaching their target destination in the intestines[75].
Immune suppression concerns: A classic 1990 study found that stearic acid (the fatty acid in magnesium stearate) suppressed T-cell function in rats, though later research suggested this effect may not occur in humans at typical supplementation levels[76]. Nevertheless, the uncertainty has led many health-conscious consumers to prefer stearate-free products.
Manufacturing stress: Studies on probiotic manufacturing have found that compression processes using lubricants can stress bacterial cells, potentially reducing viability. Research on filler-binders shows that certain additives may impact probiotic survival during tablet production[77].
Silicon Dioxide and Other Anti-Caking Agents
Silicon dioxide (silica) is commonly used to prevent powder ingredients from clumping. While generally considered safe in small amounts, recent research has raised questions about its effects on gut health:
A 2020 study found that food-grade silica particles could alter gut microbiota composition and potentially affect immune function in the intestinal tract[78]. The researchers noted that while regulatory limits consider silica safe for toxicity, the effects on beneficial gut bacteria and immune cells warrant further investigation.
For a probiotic supplement specifically designed to support gut microbiota, including an additive that may disrupt bacterial populations is counterintuitive.
HPMC Capsules vs. Pullulan: A Superior Delivery System
Most supplement capsules are made from either gelatin (animal-derived) or hydroxypropyl methylcellulose (HPMC), a semi-synthetic polymer. While HPMC capsules are vegetarian and generally functional, they offer no nutritional benefit—they're simply containers that eventually pass through your system undigested.
MicroBiome Restore uses fermented pullulan capsules, representing a significant advancement in probiotic delivery:
Plant-based and natural: Pullulan is produced through fermentation of tapioca by the fungus Aureobasidium pullulans, making it a natural, vegetarian capsule material.
Prebiotic breakdown: Unlike HPMC, pullulan capsules are broken down in the large intestine into short-chain fatty acids, providing additional nutrition for gut bacteria. The capsule itself becomes food for your microbiome.
Optimal dissolution: Pullulan capsules dissolve at the right rate to deliver probiotics to the lower intestine where they're most needed, without premature breakdown in the stomach.
This innovative capsule choice means every component of MicroBiome Restore—even the delivery system—supports gut health rather than serving as inert packaging.
The True Cost of "Cheap" Manufacturing
Manufacturers use fillers and flow agents for one primary reason: they make production easier and cheaper. Ingredients flow more smoothly through equipment, tablets compress more reliably, and production speeds increase. These additives benefit the manufacturer's bottom line, not your health.
Formulating without these additives requires more sophisticated manufacturing processes, higher-quality equipment, and more careful handling—all of which increase costs. But the result is a product where every ingredient serves a biological purpose: supporting, feeding, or delivering beneficial bacteria to your gut.
MicroBiome Restore's commitment to zero fillers means you get maximum value from every capsule—no space wasted on substances that don't contribute to gut health, and no potential interference with the probiotics you're taking.
Usage Protocol & Optimization: How to Get the Best Results
Even the highest-quality probiotic supplement works best when taken correctly and combined with supportive lifestyle practices. Here's how to optimize your results with MicroBiome Restore.
Recommended Dosing
The standard dose is 2 capsules once daily, providing 15 billion CFU of probiotics plus the complete prebiotic blend (1,470 mg). This delivers the formula as it was researched and designed, with strain ratios optimized for synergistic effects.
For most people, this once-daily dose provides comprehensive gut health support. Some individuals with significant gut dysbiosis or recent antibiotic use may benefit from temporarily increasing to 2 capsules twice daily (morning and evening) for the first 2-4 weeks, then returning to the standard maintenance dose. However, it's always best to consult with a healthcare provider before exceeding the recommended dose.
Timing and Administration
Take before your first meal: While the soil-based organisms and many traditional strains in MicroBiome Restore survive stomach acid well, taking the supplement before your first meal (on an empty or nearly-empty stomach) may allow for optimal transit through the digestive tract. The small amount of water you take with the capsules is sufficient.
With a beverage of choice: You can take MicroBiome Restore with water, a smoothie, or another beverage. Some people find that taking it with a small amount of food helps if they have very sensitive stomachs, though this isn't typically necessary.
Consistency matters most: The single most important factor isn't precisely when you take your probiotic, but that you take it consistently at approximately the same time each day. This helps establish a routine and ensures continuous support for your gut microbiome.
Enhancing Results with Trace Minerals
For accelerated results, consider combining MicroBiome Restore with X-Cellerator Full Spectrum Minerals. This complementary product provides concentrated trace minerals in liquid form, which can be added to the water you use when taking your probiotic.
The rationale is straightforward: bacterial metabolism requires mineral cofactors. While MicroBiome Restore includes 80+ trace minerals from sea vegetables, supplementing with additional concentrated minerals may help probiotics establish and multiply more rapidly, particularly if you have mineral deficiencies from poor diet or soil depletion in the food supply.
Many customers report faster and more pronounced improvements when combining these two products—the comprehensive Gut Essentials Protocol approach addresses both microbiome balance and the mineral foundation that supports bacterial metabolism.
Storage and Shelf Life
MicroBiome Restore is shelf-stable at room temperature, with the full 15 billion CFU guaranteed through the expiration date printed on the bottle. For optimal longevity:
- Store in a cool, dry place away from direct sunlight
- Keep the lid tightly closed when not in use to minimize moisture exposure
- Avoid storing in hot locations (like a car in summer)
- Refrigeration is optional—it won't hurt, but it's not necessary
The shelf stability makes MicroBiome Restore convenient for travel, office use, or keeping in your purse or gym bag without worrying about potency loss.
What to Expect: Realistic Timeline for Results
Individual responses vary based on the current state of your gut microbiome, diet, stress levels, and specific health concerns. However, here's what customers commonly report:
Days 1-3 (Adjustment Period): Some people notice mild changes in bowel movements or slight gas as the gut microbiome begins to shift. This is normal and typically resolves quickly. A small percentage of people may experience temporary increased bloating as beneficial bacteria compete with existing organisms—this usually indicates the probiotics are working.
Days 4-7 (Early Improvements): Many customers report noticeable reduction in bloating, improved bowel regularity, and decreased gas. Digestive comfort after meals may improve. Energy levels may begin to increase as nutrient absorption improves.
Weeks 2-4 (Significant Changes): This is when most people experience substantial improvements. IBS symptoms typically show meaningful reduction. Bowel movements become more regular and comfortable. Bloating decreases significantly. Some people notice improvements in skin clarity, energy, and overall wellbeing.
Weeks 4-8 (Microbiome Rebalancing): Continued improvement and stabilization. Your gut microbiome is becoming more diverse and balanced. Benefits become more consistent rather than fluctuating day-to-day. Food tolerances may improve as gut barrier function strengthens.
Beyond 8 Weeks (Long-term Maintenance): Optimal gut health becomes your new normal. Many people find they can handle occasional dietary indiscretions better. Immune function improvements may become apparent (fewer colds, better recovery). Mental clarity and mood often improve through gut-brain axis optimization.
Keep in mind this timeline represents average experiences—some people notice dramatic improvements within days, while others require 6-8 weeks for full benefits. Consistency is key.
Supporting Your Probiotic with Lifestyle Factors
To maximize the effectiveness of MicroBiome Restore, consider these supportive practices:
Eat diverse, fiber-rich foods: While the formula includes comprehensive prebiotics, consuming a variety of plant foods provides additional prebiotic fibers and polyphenols that beneficial bacteria use. Aim for 30+ different plant foods weekly if possible.
Minimize probiotic antagonists: Limit alcohol consumption, minimize artificial sweeteners, avoid unnecessary antibiotics (when safe to do so), and reduce processed foods high in additives that may harm beneficial bacteria.
Manage stress: Chronic stress directly impacts gut motility, secretions, and microbial balance through the gut-brain axis. Incorporate stress management practices like meditation, adequate sleep, regular exercise, and relaxation techniques.
Stay hydrated: Adequate water intake supports healthy digestion, helps probiotics transit through your system, and maintains the mucus layer where beneficial bacteria colonize. Aim for at least 8 glasses daily.
Consider intermittent fasting: Giving your digestive system periodic breaks (such as a 12-16 hour overnight fast) may support beneficial bacteria and gut barrier repair, though this should be discussed with a healthcare provider.
Combining with Other Supplements
MicroBiome Restore can generally be taken alongside most other supplements. However, a few considerations:
Antibiotics: If prescribed antibiotics, continue taking MicroBiome Restore (particularly because the soil-based organisms are antibiotic-resistant), but separate dosing by at least 2 hours from antibiotic administration when possible.
Digestive enzymes: Can be taken together, though some prefer to take enzymes with meals and probiotics before the first meal or at bedtime.
Other probiotics: Generally unnecessary if you're taking MicroBiome Restore, which already provides comprehensive multi-strain support. Taking multiple probiotic products simultaneously typically doesn't provide additional benefits.
Prebiotics: The formula already includes 7 organic prebiotics, so additional prebiotic supplementation isn't necessary for most people, though eating prebiotic-rich foods is always beneficial.
As always, discuss your supplement regimen with a qualified healthcare provider, especially if you have medical conditions or take prescription medications.
Quality Assurance & Manufacturing Standards
The effectiveness of a probiotic supplement depends not just on what's in the formula, but on how it's manufactured, tested, and stored. MicroBiome Restore is produced to pharmaceutical-grade standards that ensure purity, potency, and safety.
Formulation by Scientists
MicroBiome Restore was developed by scientists with advanced degrees in neuroscience and microbiology—not marketers looking to create a "me-too" product. This scientific foundation is evident in the formulation choices:
- Strain selection based on published clinical research rather than cost or availability
- Inclusion of soil-based organisms recognized for superior survivability
- Comprehensive prebiotic blend with multiple fiber types and mineral sources
- CFU count calibrated to the research-backed sweet spot (15 billion) rather than inflated numbers for marketing appeal
- Absolute exclusion of fillers and additives that might compromise efficacy
This research-first approach means MicroBiome Restore is formulated for clinical effectiveness, not just impressive-sounding label claims.
Organic Certification and Clean Sourcing
All 7 prebiotic ingredients in MicroBiome Restore are certified organic, ensuring they're:
- Free from synthetic pesticides and herbicides that could harm gut bacteria
- Non-GMO and derived from traditional breeding methods
- Produced using sustainable farming practices
- Subject to rigorous third-party certification standards
The sea vegetables (Norwegian kelp, bladderwrack, oarweed) are sourced from clean, cold North Atlantic waters where they naturally accumulate trace minerals without heavy metal contamination. Each batch is tested to ensure purity and safety.
Temperature-Controlled Processing
Probiotic bacteria are living organisms sensitive to heat, moisture, and mechanical stress. MicroBiome Restore is manufactured using temperature-controlled processes throughout:
- Freeze-drying (lyophilization): Bacteria are carefully dried at low temperatures with maltodextrin protection, preserving viability without damage
- Controlled blending: Ingredients are combined in climate-controlled facilities to prevent moisture exposure
- Protective packaging: Capsules are packaged in bottles with desiccants and sealed to prevent moisture ingress during storage
This careful handling ensures that the 15 billion CFU on the label represent viable, active bacteria—not dead cells that passed through harsh processing.
Third-Party Testing
Each batch of MicroBiome Restore undergoes comprehensive third-party testing to verify:
- Identity and potency: Confirming the specified bacterial strains are present at the labeled CFU count
- Purity: Testing for heavy metals, microbial contaminants, and adulterants
- Stability: Verifying that probiotics maintain viability through the expiration date
- Allergen screening: Confirming absence of common allergens (gluten, dairy, soy, nuts)
This rigorous testing provides confidence that what's on the label accurately reflects what's in the bottle.
Purity Guarantees
MicroBiome Restore is formulated to be inclusive and safe for diverse dietary needs:
- 100% Vegan: No animal-derived ingredients, including in the pullulan capsules
- Non-GMO: All ingredients from non-genetically-modified sources
- Gluten-Free: Safe for those with celiac disease or gluten sensitivity
- Dairy-Free: No milk-derived ingredients or lactose
- Soy-Free: No soy proteins or derivatives
- Nut-Free: Manufactured in a facility free from tree nuts and peanuts
- Corn-Free: No corn derivatives
- Artificial-Free: No artificial colors, flavors, sweeteners, or preservatives
This clean formulation makes MicroBiome Restore suitable for individuals with multiple dietary restrictions or sensitivities.
Frequently Asked Questions
How long does it take to see results from MicroBiome Restore?
Most customers report noticeable changes within 3-7 days, including reduced bloating and improved bowel regularity. Significant improvements in digestive comfort and IBS symptoms typically occur within 2-4 weeks of consistent use. However, individual timelines vary based on the starting condition of your gut microbiome, diet, stress levels, and specific health concerns. For optimal results, we recommend giving the product at least 4 weeks of daily use before fully evaluating its effectiveness.
Do I need to refrigerate MicroBiome Restore?
No, MicroBiome Restore is shelf-stable and does not require refrigeration. The formula is designed with naturally resilient soil-based organisms and robust traditional probiotic strains that maintain full potency at room temperature through the expiration date. Store the bottle in a cool, dry place away from direct sunlight. While refrigeration won't harm the product, it's not necessary and makes the supplement more convenient for travel or daily use.
Can I take MicroBiome Restore if I have IBS or SIBO?
Yes, MicroBiome Restore was specifically formulated to support individuals with IBS and digestive sensitivities. The formula includes multiple probiotic strains with clinical research supporting their use for IBS symptom relief, including Lactobacillus plantarum, Bifidobacterium infantis, and Bifidobacterium lactis. Customers with IBS commonly report improvements in bloating, abdominal discomfort, and bowel regularity within the first 2-4 weeks. For SIBO specifically, the soil-based organisms may be particularly beneficial as they're less likely to contribute to small intestinal bacterial overgrowth. However, if you have severe digestive conditions, consult with your healthcare provider before starting any new supplement.
Is MicroBiome Restore safe during pregnancy or while breastfeeding?
While the probiotic strains in MicroBiome Restore are generally considered safe, pregnant and breastfeeding women should always consult with their healthcare provider before starting any new supplement. Many obstetricians do recommend probiotics during pregnancy for digestive support and potential benefits for both mother and baby, but individual circumstances vary. Your doctor can advise whether MicroBiome Restore is appropriate for your specific situation.
Why does MicroBiome Restore contain maltodextrin?
The non-GMO rice and tapioca maltodextrins in MicroBiome Restore serve as protective substrates during the freeze-drying process, not as fillers. These substrates form a protective matrix around probiotic bacteria during processing and storage, significantly improving their survival and maintaining the guaranteed 15 billion CFU through the expiration date without requiring refrigeration. When consumed, they also provide an initial energy source that helps probiotics activate as they reach your intestines. This is a functional ingredient that serves a specific purpose for probiotic viability, distinct from cheap fillers like microcrystalline cellulose that provide no benefit.
Can I take MicroBiome Restore with antibiotics?
Yes, and in fact, taking MicroBiome Restore during and after antibiotic therapy is highly recommended to help prevent antibiotic-associated digestive problems. The soil-based organisms in the formula are particularly valuable here because their spore-forming nature makes them inherently resistant to many antibiotics. To maximize effectiveness, take MicroBiome Restore at least 2 hours separated from your antibiotic dose when possible. Continue taking the probiotic for at least 4-6 weeks after completing antibiotic therapy to help restore gut microbiome diversity.
What's the difference between MicroBiome Restore and other probiotics?
Several key factors distinguish MicroBiome Restore: (1) 26 diverse strains including both traditional probiotics and resilient soil-based organisms, providing more comprehensive support than typical 1-3 strain products; (2) 7 certified organic prebiotics totaling 1,470 mg per serving, ensuring probiotics have the nutrition needed to colonize effectively; (3) 80+ trace minerals from sea vegetables that bacteria need for metabolism; (4) Absolutely no fillers, flow agents, or additives—every ingredient serves a biological purpose; (5) Fermented pullulan capsules that break down into beneficial short-chain fatty acids; (6) Formulated by scientists with backgrounds in neuroscience and microbiology based on clinical research rather than marketing trends.
Will MicroBiome Restore cause gas or bloating initially?
A small percentage of people may experience mild, temporary gas or changes in bowel movements during the first few days as their gut microbiome begins to rebalance. This is generally a positive sign that the probiotics are actively working to shift bacterial populations. These adjustment symptoms typically resolve within 3-5 days. To minimize any initial discomfort, ensure you're staying well-hydrated and consider starting with one capsule daily for the first few days before increasing to the full dose of two capsules. The gentle, low-FODMAP prebiotic blend in MicroBiome Restore is formulated to minimize digestive upset even in sensitive individuals.
How does MicroBiome Restore compare to fermented foods?
Fermented foods like yogurt, kefir, sauerkraut, and kimchi are valuable sources of probiotics and should be included in a healthy diet when possible. However, MicroBiome Restore offers several advantages: (1) Guaranteed CFU counts with specific beneficial strains, whereas fermented foods have variable and often unknown bacterial content; (2) Inclusion of soil-based organisms that are rarely found in fermented foods but offer unique benefits; (3) Comprehensive prebiotic support and trace minerals in one convenient dose; (4) Consistency and convenience for daily use; (5) No refrigeration needed; (6) Suitable for those with dairy or gluten sensitivities. Think of MicroBiome Restore as your foundation of gut health support, with fermented foods as a beneficial dietary addition.
What's your return policy if MicroBiome Restore doesn't work for me?
We offer a 30-day money-back guarantee on MicroBiome Restore. If you don't notice meaningful improvement in your digestive comfort and gut health within the first 30 days, you can return the product for a full refund—no questions asked. We also have a 60-day return policy for unopened bottles purchased as part of bundles. This guarantee reflects our confidence that MicroBiome Restore delivers real results for the vast majority of users. Contact us at info@biophysicsessentials.com to initiate a return if needed.
Conclusion: Invest in Your Gut Health with Confidence
Your gut microbiome is the foundation of your health—influencing digestion, immune function, mental clarity, energy levels, and even your risk for chronic diseases. Yet most probiotic supplements on the market are formulated for manufacturing convenience rather than clinical effectiveness, filled with cheap fillers that may work against the very gut health you're trying to improve.
MicroBiome Restore represents a different approach: science-first formulation by researchers who understand both microbiology and the clinical evidence, 26 diverse probiotic strains including resilient soil-based organisms, 7 certified organic prebiotics with 80+ trace minerals, and absolutely no fillers or additives. Every ingredient serves a biological purpose. Every design decision prioritizes your gut health over manufacturing convenience.
The results speak for themselves. Customers commonly report:
- Noticeable reduction in bloating within the first week
- Improved bowel regularity and digestive comfort
- Significant relief from IBS symptoms within 2-4 weeks
- Better tolerance to previously problematic foods
- Increased energy and overall wellbeing
Whether you're dealing with chronic digestive issues like IBS or SIBO, recovering from antibiotic use, managing food sensitivities, or simply seeking to maintain optimal gut health in the face of modern dietary and environmental challenges, MicroBiome Restore provides comprehensive support backed by clinical science.
This isn't just another probiotic supplement. It's a no-compromise approach to gut health restoration—formulated by scientists, manufactured to pharmaceutical standards, and designed to deliver real, measurable improvements in how you feel every day.
Your gut health is too important to compromise with inferior products filled with cheap fillers and inadequate bacterial diversity. Try MicroBiome Restore risk-free with our 30-day money-back guarantee and experience the difference that a truly comprehensive, research-backed probiotic formula can make.
References
- Laudisi, F., Stolfi, C., & Monteleone, G. (2019). Impact of Food Additives on Gut Homeostasis. Nutrients, 11(10), 2334. https://doi.org/10.3390/nu11102334
- Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012). Diversity, stability and resilience of the human gut microbiota. Nature, 489(7415), 220-230. https://doi.org/10.1038/nature11550
- Hungin, A. P., Mulligan, C., Pot, B., Whorwell, P., Agréus, L., Fracasso, P., Lionis, C., Mendive, J., Philippart de Foy, J. M., Rubin, G., Winchester, C., & de Wit, N. (2013). Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice -- an evidence-based international guide. Alimentary Pharmacology & Therapeutics, 38(8), 864-886. https://doi.org/10.1111/apt.12460
- Cutting, S. M. (2011). Bacillus probiotics. Food Microbiology, 28(2), 214-220. https://doi.org/10.1016/j.fm.2010.03.007
- Elshaghabee, F. M. F., Rokana, N., Gulhane, R. D., Sharma, C., & Panwar, H. (2017). Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives. Frontiers in Microbiology, 8, 1490. https://doi.org/10.3389/fmicb.2017.01490
- Vetvicka, V., & Vetvickova, J. (2014). Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Annals of Translational Medicine, 2(2), 14. https://doi.org/10.3978/j.issn.2305-5839.2014.01.05
- Cherry, P., O'Hara, C., Magee, P. J., McSorley, E. M., & Allsopp, P. J. (2019). Risks and benefits of consuming edible seaweeds. Nutrition Reviews, 77(5), 307-329. https://doi.org/10.1093/nutrit/nuy066
- Fitton, J. H., Stringer, D. N., & Karpiniec, S. S. (2015). Therapies from Fucoidan: An Update. Marine Drugs, 13(9), 5920-5946. https://doi.org/10.3390/md13095920
- Shannon, E., & Abu-Ghannam, N. (2019). Seaweeds as nutraceuticals for health and nutrition. Phycologia, 58(5), 563-577. https://doi.org/10.1080/00318884.2019.1640533
- Vinson, J. A., Zubik, L., Bose, P., Samman, N., & Proch, J. (2005). Dried fruits: excellent in vitro and in vivo antioxidants. Journal of the American College of Nutrition, 24(1), 44-50. https://doi.org/10.1080/07315724.2005.10719442
- Roberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., Wolvers, D., Watzl, B., Szajewska, H., Stahl, B., Guarner, F., Respondek, F., Whelan, K., Coxam, V., Davicco, M. J., Léotoing, L., Wittrant, Y., Delzenne, N. M., Cani, P. D., Neyrinck, A. M., & Meheust, A. (2010). Prebiotic effects: metabolic and health benefits. British Journal of Nutrition, 104 Suppl 2, S1-63. https://doi.org/10.1017/S0007114510003363
- Cherbut, C., Michel, C., Raison, V., Kravtchenko, T., & Severine, M. (2003). Acacia gum is a bifidogenic dietary fibre with high digestive tolerance in healthy humans. Microbial Ecology in Health and Disease, 15(1), 43-50. https://doi.org/10.1080/08910600310014377
- Laudisi, F., Stolfi, C., & Monteleone, G. (2019). Impact of Food Additives on Gut Homeostasis. Nutrients, 11(10), 2334. https://doi.org/10.3390/nu11102334
- Tebbey, P. W., & Buttke, T. M. (1990). Molecular basis for the immunosuppressive action of stearic acid on T cells. Immunology, 70(3), 379-384. PMID: 2116407
- Pele, L. C., Thoree, V., Bruggraber, S. F., Koller, D., Thompson, R. P., Lomer, M. C., & Powell, J. J. (2015). Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers. Particle and Fibre Toxicology, 12, 26. https://doi.org/10.1186/s12989-015-0101-9
- Lacy, B. E., Cangemi, D., & Vazquez-Roque, M. (2021). Management of Chronic Abdominal Distension and Bloating. Clinical Gastroenterology and Hepatology, 19(2), 219-231.e1. https://doi.org/10.1016/j.cgh.2020.03.056
- Ducrotté, P., Sawant, P., & Jayanthi, V. (2012). Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World Journal of Gastroenterology, 18(30), 4012-4018. https://doi.org/10.3748/wjg.v18.i30.4012
- Ringel-Kulka, T., Palsson, O. S., Maier, D., Carroll, I., Galanko, J. A., Leyer, G., & Ringel, Y. (2011). Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. Journal of Clinical Gastroenterology, 45(6), 518-525. https://doi.org/10.1097/MCG.0b013e31820ca4d6
- Quigley, E. M. M. (2019). The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO). Current Gastroenterology Reports, 21(1), 3. https://doi.org/10.1007/s11894-019-0671-z
- Cherbut, C., Michel, C., Raison, V., Kravtchenko, T., & Severine, M. (2003). Acacia gum is a bifidogenic dietary fibre with high digestive tolerance in healthy humans. Microbial Ecology in Health and Disease, 15(1), 43-50. https://doi.org/10.1080/08910600310014377
- Ford, A. C., Lacy, B. E., & Talley, N. J. (2017). Irritable Bowel Syndrome. New England Journal of Medicine, 376(26), 2566-2578. https://doi.org/10.1056/NEJMra1607547
- Whorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. (2006). Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. American Journal of Gastroenterology, 101(7), 1581-1590. https://doi.org/10.1111/j.1572-0241.2006.00734.x
- Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., Ouwehand, A., Leyer, G., Carcano, D., Colombel, J. F., Ardid, D., & Desreumaux, P. (2007). Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nature Medicine, 13(1), 35-37. https://doi.org/10.1038/nm1521
- Martoni, C. J., Srivastava, S., & Leyer, G. J. (2020). Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients, 12(2), 363. https://doi.org/10.3390/nu12020363
- Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F. P., Cominetti, O., Welsh, C., Rieder, A., Traynor, J., Gregory, C., De Palma, G., Pigrau, M., Ford, A. C., Macri, J., Berner, B., Bergonzelli, G., Surette, M. G., Collins, S. M., Moayyedi, P., & Bercik, P. (2017). Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology, 153(2), 448-459.e8. https://doi.org/10.1053/j.gastro.2017.05.003
- Guarner, F., Khan, A. G., Garisch, J., Eliakim, R., Gangl, A., Thomson, A., Krabshuis, J., Lemair, T., Kaufmann, P., de Paula, J. A., Fedorak, R., Shanahan, F., Sanders, M. E., Szajewska, H., Ramakrishna, B. S., Karakan, T., & Kim, N. (2012). World Gastroenterology Organisation Global Guidelines: probiotics and prebiotics October 2011. Journal of Clinical Gastroenterology, 46(6), 468-481. https://doi.org/10.1097/MCG.0b013e3182549092
- Vighi, G., Marcucci, F., Sensi, L., Di Cara, G., & Frati, F. (2008). Allergy and the gastrointestinal system. Clinical and Experimental Immunology, 153 Suppl 1(Suppl 1), 3-6. https://doi.org/10.1111/j.1365-2249.2008.03713.x
- Gill, H. S., & Guarner, F. (2004). Probiotics and human health: a clinical perspective. Postgraduate Medical Journal, 80(947), 516-526. https://doi.org/10.1136/pgmj.2003.008664
- Elshaghabee, F. M. F., Rokana, N., Gulhane, R. D., Sharma, C., & Panwar, H. (2017). Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives. Frontiers in Microbiology, 8, 1490. https://doi.org/10.3389/fmicb.2017.01490
- Vetvicka, V., & Vetvickova, J. (2014). Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Annals of Translational Medicine, 2(2), 14. https://doi.org/10.3978/j.issn.2305-5839.2014.01.05
- Prasad, A. S. (2008). Zinc in human health: effect of zinc on immune cells. Molecular Medicine, 14(5-6), 353-357. https://doi.org/10.2119/2008-00033.Prasad
- Dethlefsen, L., & Relman, D. A. (2011). Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proceedings of the National Academy of Sciences, 108 Suppl 1(Suppl 1), 4554-4561. https://doi.org/10.1073/pnas.1000087107
- Ianiro, G., Rizzatti, G., Plomer, M., Lopetuso, L., Scaldaferri, F., Franceschi, F., Cammarota, G., & Gasbarrini, A. (2018). Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 10(11), 1074. https://doi.org/10.3390/nu10081074
- Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016). Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials. Genome Medicine, 8(1), 52. https://doi.org/10.1186/s13073-016-0300-5
- Lynch, S. V., & Pedersen, O. (2016). The Human Intestinal Microbiome in Health and Disease. New England Journal of Medicine, 375(24), 2369-2379. https://doi.org/10.1056/NEJMra1600266
- Mayer, E. A. (2011). Gut feelings: the emerging biology of gut-brain communication. Nature Reviews Neuroscience, 12(8), 453-466. https://doi.org/10.1038/nrn3071
- O'Callaghan, A., & van Sinderen, D. (2016). Bifidobacteria and Their Role as Members of the Human Gut Microbiota. Frontiers in Microbiology, 7, 925. https://doi.org/10.3389/fmicb.2016.00925
- Wong, C. B., Odamaki, T., & Xiao, J. Z. (2019). Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: Modulation of gut microbiome as the principal action. Journal of Functional Foods, 54, 506-519. https://doi.org/10.1016/j.jff.2019.02.002
- Groeger, D., O'Mahony, L., Murphy, E. F., Bourke, J. F., Dinan, T. G., Kiely, B., Shanahan, F., & Quigley, E. M. (2013). Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes, 4(4), 325-339. https://doi.org/10.4161/gmic.25487
- Gomi, A., Yamaji, K., Watanabe, O., Yoshioka, M., Miyazaki, K., Iwama, Y., Urita, Y., & Kuwahara, T. (2018). Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, placebo-controlled study. Journal of Dairy Science, 101(6), 4830-4841. https://doi.org/10.3168/jds.2017-13803
- Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F. P., Cominetti, O., Welsh, C., Rieder, A., Traynor, J., Gregory, C., De Palma, G., Pigrau, M., Ford, A. C., Macri, J., Berner, B., Bergonzelli, G., Surette, M. G., Collins, S. M., Moayyedi, P., & Bercik, P. (2017). Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology, 153(2), 448-459.e8. https://doi.org/10.1053/j.gastro.2017.05.003
- Fijan, S. (2014). Microorganisms with claimed probiotic properties: an overview of recent literature. International Journal of Environmental Research and Public Health, 11(5), 4745-4767. https://doi.org/10.3390/ijerph110504745
- Hojsak, I., Abdović, S., Szajewska, H., Milošević, M., Krznarić, Ž., & Kolaček, S. (2010). Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics, 125(5), e1171-e1177. https://doi.org/10.1542/peds.2009-2568
- Saxelin, M., Tynkkynen, S., Mattila-Sandholm, T., & de Vos, W. M. (2005). Probiotic and other functional microbes: from markets to mechanisms. Current Opinion in Biotechnology, 16(2), 204-211. https://doi.org/10.1016/j.copbio.2005.02.003
- Turpin, W., Humblot, C., Thomas, M., & Guyot, J. P. (2010). Lactobacilli as multifaceted probiotics with poorly disclosed molecular mechanisms. International Journal of Food Microbiology, 143(3), 87-102. https://doi.org/10.1016/j.ijfoodmicro.2010.07.032
- Kadooka, Y., Sato, M., Ogawa, A., Miyoshi, M., Uenishi, H., Ogawa, H., Ikuyama, K., Kagoshima, M., & Tsuchida, T. (2013). Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. British Journal of Nutrition, 110(9), 1696-1703. https://doi.org/10.1017/S0007114513001037
- Hill, C., Guarner, F., Reid, G., Gibson, G. R., Merenstein, D. J., Pot, B., Morelli, L., Canani, R. B., Flint, H. J., Salminen, S., Calder, P. C., & Sanders, M. E. (2014). Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology & Hepatology, 11(8), 506-514. https://doi.org/10.1038/nrgastro.2014.66
- Ducrotté, P., Sawant, P., & Jayanthi, V. (2012). Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World Journal of Gastroenterology, 18(30), 4012-4018. https://doi.org/10.3748/wjg.v18.i30.4012
- Mu, Q., Tavella, V. J., & Luo, X. M. (2018). Role of Lactobacillus reuteri in Human Health and Diseases. Frontiers in Microbiology, 9, 757. https://doi.org/10.3389/fmicb.2018.00757
- Doron, S., & Snydman, D. R. (2015). Risk and safety of probiotics. Clinical Infectious Diseases, 60 Suppl 2, S129-S134. https://doi.org/10.1093/cid/civ085
- Neville, B. A., & O'Toole, P. W. (2010). Probiotic properties of Lactobacillus salivarius and closely related Lactobacillus species. Future Microbiology, 5(5), 759-774. https://doi.org/10.2217/fmb.10.35
- Franz, C. M., Huch, M., Abriouel, H., Holzapfel, W., & Gálvez, A. (2011). Enterococci as probiotics and their implications in food safety. International Journal of Food Microbiology, 151(2), 125-140. https://doi.org/10.1016/j.ijfoodmicro.2011.08.014
- Solem, C., & Jensen, P. R. (2002). Modulation of gene expression made easy. Applied and Environmental Microbiology, 68(5), 2397-2403. https://doi.org/10.1128/AEM.68.5.2397-2403.2002
- Porto, M. C. W., Kuniyoshi, T. M., Azevedo, P. O. S., Vitolo, M., & Oliveira, R. P. S. (2017). Pediococcus spp.: An important genus of lactic acid bacteria and pediocin producers. Biotechnology Advances, 35(3), 361-374. https://doi.org/10.1016/j.biotechadv.2017.03.004
- Ranadheera, C. S., Vidanarachchi, J. K., Rocha, R. S., Cruz, A. G., & Ajlouni, S. (2017). Probiotic Delivery through Fermentation: Dairy vs. Non-Dairy Beverages. Fermentation, 3(4), 67. https://doi.org/10.3390/fermentation3040067
- Hungin, A. P., Mitchell, C. R., Whorwell, P., Mulligan, C., Cole, O., Agréus, L., Fracasso, P., Lionis, C., Mendive, J., Philippart de Foy, J. M., Seifert, B., Wensaas, K. A., Winchester, C., & de Wit, N. (2018). Systematic review: probiotics in the management of lower gastrointestinal symptoms - an updated evidence-based international consensus. Alimentary Pharmacology & Therapeutics, 47(8), 1054-1070. https://doi.org/10.1111/apt.14539
- Ianiro, G., Rizzatti, G., Plomer, M., Lopetuso, L., Scaldaferri, F., Franceschi, F., Cammarota, G., & Gasbarrini, A. (2018). Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 10(11), 1074. https://doi.org/10.3390/nu10081074
- Elshaghabee, F. M. F., Rokana, N., Gulhane, R. D., Sharma, C., & Panwar, H. (2017). Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives. Frontiers in Microbiology, 8, 1490. https://doi.org/10.3389/fmicb.2017.01490
- Cutting, S. M. (2011). Bacillus probiotics. Food Microbiology, 28(2), 214-220. https://doi.org/10.1016/j.fm.2010.03.007
- Vetvicka, V., & Vetvickova, J. (2014). Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Annals of Translational Medicine, 2(2), 14. https://doi.org/10.3978/j.issn.2305-5839.2014.01.05
- Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., & Cassileth, B. (2009). A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. Journal of Cancer Research and Clinical Oncology, 135(9), 1215-1221. https://doi.org/10.1007/s00432-009-0562-z
- Cherry, P., O'Hara, C., Magee, P. J., McSorley, E. M., & Allsopp, P. J. (2019). Risks and benefits of consuming edible seaweeds. Nutrition Reviews, 77(5), 307-329. https://doi.org/10.1093/nutrit/nuy066
- Shannon, E., & Abu-Ghannam, N. (2019). Seaweeds as nutraceuticals for health and nutrition. Phycologia, 58(5), 563-577. https://doi.org/10.1080/00318884.2019.1640533
- Fitton, J. H., Stringer, D. N., & Karpiniec, S. S. (2015). Therapies from Fucoidan: An Update. Marine Drugs, 13(9), 5920-5946. https://doi.org/10.3390/md13095920
- Catarino, M. D., Silva, A. M. S., & Cardoso, S. M. (2018). Phycochemical Constituents and Biological Activities of Fucus spp. Marine Drugs, 16(8), 249. https://doi.org/10.3390/md16080249
- Shannon, E., & Abu-Ghannam, N. (2019). Seaweeds as nutraceuticals for health and nutrition. Phycologia, 58(5), 563-577. https://doi.org/10.1080/00318884.2019.1640533
- Vinson, J. A., Zubik, L., Bose, P., Samman, N., & Proch, J. (2005). Dried fruits: excellent in vitro and in vivo antioxidants. Journal of the American College of Nutrition, 24(1), 44-50. https://doi.org/10.1080/07315724.2005.10719442
- Kountouri, A. M., Mylona, A., Kaliora, A. C., & Andrikopoulos, N. K. (2007). Bioavailability of the phenolic compounds of the fruits (drupes) of Olea europaea (olives): impact on plasma antioxidant status in humans. Phytomedicine, 14(10), 659-667. https://doi.org/10.1016/j.phymed.2007.05.001
- Roberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., Wolvers, D., Watzl, B., Szajewska, H., Stahl, B., Guarner, F., Respondek, F., Whelan, K., Coxam, V., Davicco, M. J., Léotoing, L., Wittrant, Y., Delzenne, N. M., Cani, P. D., Neyrinck, A. M., & Meheust, A. (2010). Prebiotic effects: metabolic and health benefits. British Journal of Nutrition, 104 Suppl 2, S1-63. https://doi.org/10.1017/S0007114510003363
- Slavin, J. (2013). Fiber and prebiotics: mechanisms and health benefits. Nutrients, 5(4), 1417-1435. https://doi.org/10.3390/nu5041417
- Cherbut, C., Michel, C., Raison, V., Kravtchenko, T., & Severine, M. (2003). Acacia gum is a bifidogenic dietary fibre with high digestive tolerance in healthy humans. Microbial Ecology in Health and Disease, 15(1), 43-50. https://doi.org/10.1080/08910600310014377
- Parisi, G. C., Zilli, M., Miani, M. P., Carrara, M., Bottona, E., Verdianelli, G., Battaglia, G., Desideri, S., Faedo, A., Marzolino, C., Tonon, A., Ermani, M., & Leandro, G. (2002). High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG). Digestive Diseases and Sciences, 47(8), 1697-1704. https://doi.org/10.1023/a:1016419906546
- Laudisi, F., Stolfi, C., & Monteleone, G. (2019). Impact of Food Additives on Gut Homeostasis. Nutrients, 11(10), 2334. https://doi.org/10.3390/nu11102334
- Batista, K. S., Alves, A. F., Lima, M. S., Silva, L. A., Lins, P. P., Gomes, J. A. S., Silva, A. S., Toscano, L. T., Lacerda, R. R., & Tavares, J. F. (2020). Beneficial effects of consumption of acerola, cashew or guava processing by-products on intestinal health and lipid metabolism in dyslipidaemic female Wistar rats. British Journal of Nutrition, 123(11), 1203-1212. https://doi.org/10.1017/S0007114520000689
- Tebbey, P. W., & Buttke, T. M. (1990). Molecular basis for the immunosuppressive action of stearic acid on T cells. Immunology, 70(3), 379-384. PMID: 2116407
- Henderson, A. J., Kumar, A., Barnett, B., Dow, S. W., & Ryan, E. P. (2012). Consumption of rice bran increases mucosal immunoglobulin A concentrations and numbers of intestinal Lactobacillus spp. Journal of Medicinal Food, 15(5), 469-475. https://doi.org/10.1089/jmf.2011.0213
- Saarela, M., Hallamaa, K., Mattila-Sandholm, T., & Mättö, J. (2003). The effect of lactose derivatives lactulose, lactitol and lactobionic acid on the functional and technological properties of potentially probiotic Lactobacillus strains. International Dairy Journal, 13(4), 291-302. https://doi.org/10.1016/S0958-6946(02)00158-9
- Pele, L. C., Thoree, V., Bruggraber, S. F., Koller, D., Thompson, R. P., Lomer, M. C., & Powell, J. J. (2015). Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers. Particle and Fibre Toxicology, 12, 26. https://doi.org/10.1186/s12989-015-0101-9


Share and get 15% off!
Simply share this product on one of the following social networks and you will unlock 15% off!