Probiotics for Gum Health: The Evidence-Based Strains That Actually Move the Needle on Periodontal Disease
What the clinical research really says—and why your gut microbiome is part of the equation
If you've been told that gum disease is simply a matter of brushing and flossing better, the emerging science suggests the picture is considerably more complex. Periodontal disease—the umbrella term for gum inflammation ranging from gingivitis to destructive periodontitis—is driven fundamentally by microbial imbalance. And that imbalance doesn't begin and end at the gumline.
Research on the oral-gut axis has revealed a bidirectional connection between the mouth and the gut that has major implications for how we understand gum disease. Swallowed periodontal pathogens can colonize the gut and trigger systemic inflammation. Conversely, gut dysbiosis can worsen periodontal destruction through immune imbalance and systemic inflammatory burden.[1] The two ecosystems are not separate—they are interconnected, and a dysbiotic gut can undermine even a healthy oral care routine.
This is where gut-targeted probiotics enter the picture. A growing body of peer-reviewed evidence shows that probiotic strains—particularly those from the Lactobacillus and Bifidobacterium genera—can measurably improve clinical markers of gum disease: reducing pocket depth, cutting gingival bleeding, suppressing periodontal pathogens, and dampening the inflammatory cytokines that drive tissue destruction.[2]
This guide examines the clinical evidence for specific probiotic strains found in MicroBiome Restore that have demonstrated meaningful effects on gum health and periodontal disease—without overstating what we know or ignoring the limitations of the current research.
Key Takeaways
- Probiotics significantly improve core clinical markers of periodontal disease. A meta-analysis of 64 randomized clinical trials found statistically significant improvements in plaque index, gingival index, probing pocket depth, clinical attachment level, and bleeding on probing following probiotic supplementation.[2]
- Lactobacillus reuteri is the most extensively studied probiotic for gum disease, appearing in 17 of 36 reviewed RCTs in one major systematic review, with demonstrated reductions in gingival inflammation, bleeding on probing, and periodontal pocket depth.[3]
- The oral-gut axis is a two-way highway. Periodontal pathogens swallowed into the gut can induce gut dysbiosis and drive systemic inflammation; gut dysbiosis in turn worsens periodontal tissue destruction.[1]
- L. rhamnosus and L. plantarum effectively inhibit key periodontal pathogens, including Porphyromonas gingivalis and Fusobacterium nucleatum, with multiple RCTs supporting their role in both gingivitis prevention and periodontal supportive therapy.[4]
- Bacillus subtilis and Bacillus licheniformis reduced alveolar bone loss in experimental periodontitis models and enhanced the effects of scaling and root planing treatment.[5]
- Probiotic supplementation reduced inflammatory cytokines (IL-6, TNF-α, IL-1β) in periodontal tissue, offering a plausible immunological mechanism for the clinical improvements seen in trials.[2]
The Oral-Gut Axis: Why Your Gut Microbiome Affects Your Gums
Most people think of gum disease as a purely local problem—bacteria accumulate in the mouth, the immune system overreacts, and gum tissue is damaged. But the science of the oral-gut axis tells a more complicated and more consequential story.
The oral cavity and the gastrointestinal tract are directly connected. Every day, between 1–1.5 liters of saliva are swallowed, carrying with it a substantial microbial payload. In healthy individuals, stomach acid and the established gut microbiome prevent these oral bacteria from taking root in the intestines. But in individuals with gut dysbiosis or compromised barrier function, periodontal pathogens like Porphyromonas gingivalis and Fusobacterium nucleatum can survive transit and colonize the gut—triggering dysbiosis, disrupting intestinal barrier integrity, and escalating systemic inflammation.[1]
The Bidirectional Connection
A 2023 review published in the Journal of Periodontal Research describes the oral-gut axis as a novel biological mechanism linking periodontal disease to systemic conditions including diabetes, atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. Critically, the relationship is bidirectional: gut dysbiosis increases Th17/Treg immune imbalance and reduces short-chain fatty acid production, both of which worsen periodontal tissue destruction. Restoring the gut microbiome may therefore reduce susceptibility to gum disease through systemic pathways—not just oral ones.[1]
This bidirectional relationship has a direct implication for how we should think about probiotic supplementation. A gut-targeted probiotic that supports a healthy, diverse gut microbiome doesn't just benefit digestion—it may reduce the systemic inflammatory burden that makes gum tissue vulnerable to destruction in the first place. For those interested in how gut bacteria affect inflammation more broadly, our article on the role of gut bacteria in mucosal lining health covers the foundational mechanisms.
The Prevalence Problem
Periodontal disease affects more than 50% of adults in the United States in some form—making it one of the most widespread chronic inflammatory conditions in the country. Severe periodontitis, which can result in tooth loss and contributes to systemic inflammatory load, affects roughly 8–10% of adults globally.[6] Conventional management involves professional cleaning (scaling and root planing, or SRP), antimicrobials, and oral hygiene maintenance. Probiotics are emerging as evidence-backed adjuncts to this toolkit—not as replacements, but as biological tools that can shift the oral microbial environment in ways that support healing and disease prevention.
How Probiotics Work Against Periodontal Disease
Probiotic strains don't simply "kill bad bacteria." Their mechanisms of action in the oral and gut environments are more nuanced—and more interesting. Understanding these mechanisms helps explain why certain strains are better candidates than others for supporting gum health.
Competitive Exclusion
Beneficial probiotic bacteria compete directly with periodontal pathogens for adhesion sites on mucosal surfaces and tooth structures. When Lactobacillus and Bifidobacterium species occupy receptor sites on gingival epithelium, periodontal pathogens like P. gingivalis and Tannerella forsythia have fewer opportunities to establish pathogenic biofilms. This mechanism is particularly effective for strains like L. reuteri, which produces exopolysaccharides that enhance its adherence to host tissues while blocking pathogen attachment.[7]
Bacteriocin and Antimicrobial Metabolite Production
Several probiotic strains produce bacteriocins—small antimicrobial proteins—along with hydrogen peroxide, organic acids, and other metabolites that directly inhibit periodontal pathogens. L. reuteri produces reuterin and reutericyclin, compounds with broad antimicrobial activity against anaerobic gram-negative bacteria that characterize the dysbiotic periodontal pocket environment.[7] Bacillus species also produce a diverse array of antimicrobial compounds, including iturin and surfactin, that disrupt pathogenic biofilms.
Immune Modulation and Cytokine Reduction
Periodontal tissue destruction is not simply caused by bacteria—it is substantially driven by the host's own inflammatory response. Pro-inflammatory cytokines including IL-1β, TNF-α, IL-6, and IL-17 are elevated in periodontal pockets and directly stimulate matrix metalloproteinase production, leading to collagen degradation and alveolar bone loss. Probiotic strains modulate this response by stimulating regulatory T cell differentiation, reducing cytokine production, and interacting with toll-like receptors on dendritic cells in ways that dampen pathological inflammation without eliminating the immune response to pathogens.[2]
Gut-Mediated Systemic Anti-Inflammatory Effects
Gut-targeted probiotics that restore microbial diversity, strengthen the intestinal barrier, and increase short-chain fatty acid (SCFA) production can reduce systemic inflammatory markers—including those that exacerbate periodontal disease. SCFAs like butyrate have known anti-inflammatory effects at the systemic level and may reduce the Th17-driven immune response associated with periodontal bone destruction. Our guide to butyrate and SCFAs in gut health covers this pathway in depth.
Best Probiotic Strains for Gum Health and Periodontal Disease
Not all probiotic strains are equally supported by evidence for gum health. The following strains are included in MicroBiome Restore and have meaningful clinical or mechanistic evidence for their role in periodontal disease management or gum health support.
Lactobacillus reuteri
L. reuteri is the most studied probiotic strain for oral and gum health by a significant margin. A 2024 systematic review that analyzed nine clinical studies found that adjunctive use of L. reuteri in nonsurgical periodontal treatment produced improvements in probing pocket depth, bleeding on probing, gingival index, and clinical attachment level across the majority of included trials.[3] A separate 2024 systematic review and network meta-analysis of 33 RCTs involving 1,290 patients highlighted L. reuteri as the most effective probiotic for improving periodontal clinical parameters as an adjunct to professional mechanical plaque removal.[8]
The mechanisms are well-characterized: L. reuteri produces reuterin and reutericyclin that inhibit P. gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans—three of the primary culprit bacteria in periodontal disease. It also suppresses the production of pro-inflammatory cytokines, reducing the gingival inflammatory response that drives tissue damage.[7] Explore the full evidence profile for this strain in our article on Lactobacillus reuteri benefits.
Lactobacillus rhamnosus
A 2024 systematic review in Dentistry Journal, conducted per PRISMA guidelines and registered on PROSPERO, analyzed 15 RCTs and found that L. rhamnosus—both alone and in combination with other strains—had the potential to prevent and improve clinical outcomes in periodontal treatments.[4] In one RCT, a combination of L. rhamnosus and Bifidobacterium lactis was found to significantly improve gingival health, reduce dental plaque, and lower counts of periodontopathogens in adolescents compared to placebo.[9]
L. rhamnosus demonstrates strong adhesion to the primary pellicle that forms on tooth surfaces, making it effective at outcompeting periodontal pathogens for colonization sites. Both L. rhamnosus and L. paracasei—another strain in MicroBiome Restore—co-aggregate with Fusobacterium nucleatum, a bridging pathogen central to the development of the dysbiotic subgingival biofilm that characterizes periodontitis.[10]
Lactobacillus plantarum
The same PRISMA-registered systematic review found meaningful clinical support for L. plantarum in periodontal disease management, with several studies documenting its ability to inhibit the growth of P. gingivalis and Streptococcus mutans.[4] In a 3-month randomized controlled clinical trial, a combination of L. plantarum and L. brevis as adjuncts to non-surgical periodontal therapy produced significant improvements in gingival inflammation and clinical parameters compared to SRP alone.[11]
Beyond direct pathogen inhibition, L. plantarum is particularly valued for its intestinal barrier-supporting properties, which contribute to the systemic anti-inflammatory effects relevant to periodontal health. Read more about the broader evidence for L. plantarum and its health benefits.
Lactobacillus acidophilus
L. acidophilus co-aggregates with Fusobacterium nucleatum and has demonstrated inhibition of oral Candida albicans overgrowth, which can complicate periodontal disease—especially in immunocompromised individuals.[10] It is among the probiotic strains whose effects on oral pathogens are most consistently documented in the literature, and one trial showed significant reductions in periodontal parameters and halitosis following oral administration of a combination including L. reuteri, L. salivarius, and L. acidophilus over 90 days.[12]
Lactobacillus salivarius
L. salivarius is naturally isolated from the oral cavity and has been commercially developed for oral health applications. In the study cited above, its inclusion in a multi-strain formula contributed to significant reductions in periodontal parameters and halitosis over 90 days of supplementation.[12] It also possesses known antimicrobial activity against P. gingivalis in saliva and subgingival plaque. Explore what we know about Lactobacillus salivarius benefits in more depth.
Bifidobacterium lactis
In the 2024 network meta-analysis, Bifidobacterium lactis (specifically strain HN019) was singled out as producing significantly enhanced pocket closure, attachment gain, and reduced periodontal inflammation compared to placebo in clinical trials.[8] B. lactis was also included in the RCT on adolescents alongside L. rhamnosus that found significant improvements in gingival health and reductions in periodontopathogens.[9] Learn about the gut health role of Bifidobacterium lactis as well.
Bacillus subtilis and Bacillus licheniformis
A preclinical study in Archives of Oral Biology found that supplementation with Bacillus subtilis and Bacillus licheniformis provided a protective effect against alveolar bone loss in experimental periodontitis and enhanced the effectiveness of scaling and root planing treatment, reducing both attachment loss and inflammatory bone destruction.[5] A separate study published in the Journal of Clinical Periodontology found that a mouth rinse containing Bacillus subtilis significantly reduced BANA scores—a proxy measure for the presence of major periodontal pathogens—compared to a conventional antimicrobial mouth rinse.[13]
Both B. subtilis and B. licheniformis are spore-forming probiotics in MicroBiome Restore. Their spore status confers exceptional viability through the digestive system—an important practical consideration for gut-administered probiotics. Learn more about Bacillus subtilis probiotic benefits.
Bacillus coagulans
A double-blind, placebo-controlled trial found that participants who consumed Bacillus coagulans tablets for three months showed significantly lower gingival index scores and reduced bleeding on probing compared to the placebo group, with lower glutathione peroxidase activity suggesting modulation of oxidative inflammatory stress.[14] A separate trial found that B. coagulans supplementation significantly reduced oral levels of cariogenic Streptococcus mutans within 14 days.[14] Explore the gut health applications of Bacillus coagulans.
Lactobacillus fermentum and Lactobacillus casei
L. fermentum is well-studied for its antimicrobial properties and its natural presence in oral and gut ecosystems. L. casei has demonstrated inhibition of Fusobacterium nucleatum and has been included in combination studies showing reduced periodontal parameters. Both co-aggregate with primary periodontal pathogens, contributing to the competitive exclusion mechanism that supports gum health.[10]
The table below summarizes the evidence landscape for MicroBiome Restore strains with documented gum health relevance:
| Strain | Primary Mechanism for Gum Health | Key Evidence Level |
|---|---|---|
| L. reuteri | Pathogen inhibition, cytokine reduction, competitive exclusion | Multiple RCTs + systematic reviews[3] |
| L. rhamnosus | Pathogen inhibition, strong pellicle adhesion | PRISMA systematic review, RCTs[4] |
| L. plantarum | Anti-pathogenic, gut barrier support | PRISMA systematic review, RCTs[4] |
| B. lactis | Pocket closure, attachment gain, plaque reduction | RCTs, network meta-analysis[8] |
| L. acidophilus | Co-aggregation with F. nucleatum, Candida control | In vitro + clinical evidence[10] |
| L. salivarius | Antimicrobial vs. P. gingivalis, halitosis reduction | Clinical trial evidence[12] |
| B. subtilis / B. licheniformis | Bone loss protection, pathogen reduction | Preclinical + early clinical[5] |
| B. coagulans | Gingival index reduction, immune modulation | Placebo-controlled trial[14] |
26 Strains. Zero Fillers. One Daily Capsule.
MicroBiome Restore contains every strain discussed in this article—plus 19 more clinically studied strains—in a single filler-free pullulan capsule. No microcrystalline cellulose. No magnesium stearate. No titanium dioxide. Just 15 billion CFU of evidence-backed gut and immune support.
What the Clinical Evidence Actually Shows
The literature on probiotics and periodontal disease has matured considerably over the last decade. Here is an honest summary of what multiple systematic reviews and meta-analyses have established—including both the promise and the remaining uncertainties.
What Multiple Meta-Analyses Agree On
The most comprehensive meta-analysis to date, published in Microorganisms in 2022, synthesized data from 64 randomized clinical trials and found statistically significant improvements after probiotic supplementation across nearly all major clinical outcomes of periodontal disease, including plaque index, gingival index, probing pocket depth, clinical attachment level, and bleeding on probing.[2] The effect sizes were meaningful—not marginal—across all five parameters, with the largest improvements seen in gingival index and bleeding on probing, the two markers most directly associated with active gingival inflammation.
A separate 2022 meta-analysis of 21 studies confirmed that probiotics as adjuvant periodontal therapy improved pocket depth, clinical attachment loss, and bleeding on probing with statistical significance (p < 0.001 for each).[15]
A 2024 network meta-analysis of 33 RCTs involving 1,290 patients found that L. reuteri-containing probiotic formulations were the most consistently effective of all tested probiotic approaches, improving all clinical outcomes and earning the top position in the network analysis for periodontal therapy adjuncts.[8]
The Role of Probiotics vs. Antibiotics
A 2024 systematic review in Oral Diseases compared probiotics directly against antibiotics as supplemental therapies in periodontal treatment. The findings showed that probiotics outperformed antibiotics in reducing probing pocket depth and clinical attachment loss, though antibiotics were more effective for plaque and gingival indices. A combined approach—probiotics and antibiotics together—was superior to either alone.[16] This is meaningful context for a world increasingly concerned about antimicrobial resistance: probiotics appear capable of achieving some of the same tissue-level benefits as antibiotics without the collateral damage to the broader microbiome.
The Gut Health Angle Matters Here Too
One mechanism often overlooked in oral-focused probiotic research is the gut-mediated pathway. A 2024 review in Frontiers in Cellular and Infection Microbiology documented how periodontal bacteria that translocate to the gut can reduce gut microbial diversity, alter the Firmicutes/Bacteroidetes ratio, and reduce the abundance of beneficial gut bacteria—directly creating the conditions for systemic inflammation that exacerbates gum disease.[17] Supplementing with a multi-strain probiotic that restores this diversity works on both sides of the equation.
Prebiotics and Gum Health: The Supporting Role
The probiotic strains in MicroBiome Restore are supported by 9 organic prebiotics including Jerusalem artichoke (a dense source of inulin), Acacia fiber, maitake mushroom, fig fruit, bladderwrack, Norwegian kelp, and oarweed. These prebiotic fibers selectively feed the beneficial bacteria in the formula, enhancing colonization and SCFA production—particularly the butyrate pathway that has demonstrated systemic anti-inflammatory properties relevant to periodontal health. A well-fed probiotic is a more effective probiotic.
Important Caveats in the Research
The literature acknowledges genuine limitations. Studies vary considerably in probiotic strains tested, doses used, administration forms (lozenges, capsules, yogurt), duration of supplementation, and follow-up periods. Heterogeneity across trials makes direct comparison difficult. Most clinical studies also focus on oral-specific probiotic formulations rather than gut-targeted supplements—meaning the gut-mediated pathway to gum health is biologically plausible and supported by mechanistic evidence but hasn't been studied in dedicated long-term RCTs. As with all emerging nutritional science, the evidence warrants cautious optimism rather than certainty.
What to Look for in a Probiotic for Gum Health
Not all probiotics marketed for oral or systemic health are created equal. If you're considering a probiotic to support gum health, here are the criteria that actually matter.
Multi-Strain Coverage Spanning Lactobacillus and Bifidobacterium
The evidence base for gum health is concentrated in Lactobacillus species—particularly L. reuteri, L. rhamnosus, and L. plantarum—but Bifidobacterium lactis has demonstrated independent clinical value for periodontal outcomes, and broader microbial diversity correlates with better systemic immune regulation. A multi-strain formula covering both genera is preferable to a single-strain product. The 2022 meta-analysis that reviewed 64 trials specifically found that Lactobacillus probiotic formulations improved all clinical outcomes, with L. reuteri-containing formulations performing best of all subgroups tested.[2]
Filler-Free Formulation
Many commercial probiotics—even well-branded ones—contain inactive ingredients that can undermine their own effectiveness. Microcrystalline cellulose (MCC), found in the majority of supplement capsules, has raised concerns in the literature for its effects on gut motility and mucosal integrity. Magnesium stearate, a ubiquitous flow agent, may form a thin hydrophobic film that reduces probiotic colonization efficiency. Titanium dioxide—still used in some supplement coatings—has raised red flags in emerging safety research. For a probiotic that's supposed to reduce gut and systemic inflammation, introducing additives with their own inflammatory potential is counterproductive. Learning to identify hidden fillers on probiotic labels is a critical skill.
Capsule Technology That Protects Live Bacteria
The probiotic bacteria must survive the acidic stomach environment to colonize the intestines and exert systemic effects. Pullulan capsules—the capsule material used in MicroBiome Restore—are fermented from tapioca, provide natural delayed-release properties, and are themselves mildly prebiotic. This is meaningfully superior to standard gelatin capsules or hypromellose (HPMC) capsules, which don't offer the same protective properties for the probiotic contents.
Spore-Forming Strains for Survivability
Spore-forming Bacillus species—including B. subtilis, B. coagulans, B. clausii, and B. licheniformis—have a significant practical advantage: their endospore form survives stomach acid, bile, and temperature fluctuations that would inactivate many vegetative probiotic cells. This means they arrive at the gut alive and ready to germinate, colonize, and produce their antimicrobial metabolites. For gum health specifically, these strains offer systemic immune modulation and pathogen suppression that complements the more direct oral effects of Lactobacillus strains.
CFU Count in Context
The clinical trials demonstrating periodontal benefits used individual strain doses ranging from roughly 100 million to 1 billion CFU per day. A well-formulated multi-strain probiotic delivering 15 billion CFU total across many active strains provides therapeutic levels across multiple species simultaneously—covering both gut and systemic immune pathways. Higher CFU counts are not automatically more effective; the quality, viability, and diversity of strains matters far more than raw numbers.
An Important Note on Oral vs. Gut Probiotics
Most of the clinical trials on probiotics for periodontal disease used oral-delivery formats: lozenges, chewing gums, or dissolvable tablets that expose the probiotic bacteria directly to the oral cavity. A gut-administered probiotic operates through systemic and oral-gut axis pathways rather than direct oral colonization. Both approaches have legitimate scientific rationale; they work through complementary mechanisms. MicroBiome Restore is a gut health supplement—its contribution to gum health is through systemic inflammation reduction, gut microbiome restoration, and the oral-gut axis, rather than through direct oral colonization. This article is not a substitute for regular dental care and professional periodontal treatment.
Frequently Asked Questions
Can probiotics replace scaling and root planing for gum disease?
No. The clinical evidence consistently positions probiotics as adjuncts to—not replacements for—professional mechanical periodontal treatment. Even the most favorable systematic reviews show that probiotics work best when combined with professional cleaning. That said, the 2024 comparative review found that probiotics outperformed antibiotics on specific clinical parameters (pocket depth, attachment level), suggesting they're a meaningful therapeutic tool rather than just a supportive afterthought.[16] Always consult your dentist or periodontist for diagnosis and treatment of active periodontal disease.
How long do probiotics take to show effects on gum health?
Most clinical trials documenting improvements in periodontal parameters ran for four to twelve weeks of probiotic supplementation. In trials assessing L. reuteri specifically, significant reductions in gingival inflammation were observed as early as the 14–21 day mark in some studies. Sustained benefits likely require consistent, ongoing supplementation—consistent with the general principle that probiotic effects are not permanent without continued use.
Do I need a probiotic specifically made for oral health, or does a gut probiotic work?
Both approaches have scientific rationale. Oral-specific probiotics (typically lozenges) aim to directly colonize the oral cavity with beneficial bacteria. Gut-targeted probiotics work through the oral-gut axis: restoring gut microbial diversity, reducing systemic inflammatory load, and potentially influencing the composition of the oral microbiome through immune system modulation. The gut-oral connection means that a healthy gut microbiome is genuinely protective against the systemic inflammatory conditions that make gum tissue more vulnerable. Supporting that gut ecosystem is a legitimate complementary strategy—though it should not replace a targeted oral hygiene routine. For those interested in understanding single vs. multi-strain probiotics and how to evaluate formulas, we've covered that in depth.
Are there side effects from taking probiotics for gum disease?
Probiotics are broadly considered safe for healthy adults, with adverse effects rated as rare and typically mild in clinical literature. The primary concerns are limited to individuals with severely compromised immune systems, who should consult a healthcare provider before use. Mild, transient digestive changes (bloating, changes in bowel habits) can occur in the first few days of starting a probiotic, reflecting the gut microbiome adjusting to new microbial populations—this is normal and generally resolves quickly.
Is gum disease really connected to gut health?
Yes, and the science on this is becoming clearer. A 2024 review in Frontiers in Cellular and Infection Microbiology documented specific pathways by which periodontal bacteria—swallowed in saliva—translocate to the gut, cause gut dysbiosis, and through altered immune signaling and reduced short-chain fatty acid production, worsen systemic inflammation that in turn damages periodontal tissues.[17] This isn't a theoretical connection; it's a documented bidirectional relationship with implications for how both gum disease and gut health should be managed. Those experiencing multiple signs of Lactobacillus deficiency may find their gut imbalance is contributing to more than just digestive symptoms.
The Bottom Line: Probiotics, Gum Health, and the Gut Connection
The evidence on probiotics for gum health is no longer preliminary. Multiple meta-analyses spanning dozens of randomized clinical trials have established statistically significant improvements in the primary clinical markers of periodontal disease with probiotic supplementation—and the strains best supported by the evidence are L. reuteri, L. rhamnosus, L. plantarum, B. lactis, and several others present in a comprehensive multi-strain formula.
What the oral-centric literature often underweights is the gut angle: the oral-gut axis research is establishing that a disrupted gut microbiome directly worsens the systemic inflammatory conditions that predispose to—and perpetuate—gum disease. Supporting the gut with a diverse, well-formulated, filler-free probiotic is a genuine and evidence-grounded strategy for reducing that systemic burden. For those already dealing with leaky gut or intestinal barrier issues, addressing those problems may yield unexpected dividends for oral health.
If you want to understand how MicroBiome Restore's 26-strain formula was built and what it contains, our complete guide to MicroBiome Restore walks through the full ingredient rationale.
Built for Your Gut. Evidence Behind Every Strain.
MicroBiome Restore delivers 26 clinically studied probiotic strains, 9 organic prebiotics, and 80+ trace minerals—in a filler-free pullulan capsule. Every ingredient earns its place. No MCC. No magnesium stearate. No titanium dioxide.
References
- Tomofuji, T., et al. (2023). Oral-gut axis as a novel biological mechanism linking periodontal disease and systemic diseases: A review. Journal of Periodontal Research, 58(5), 1081–1092. https://doi.org/10.1111/jre.13159
- Ikram, S., et al. (2022). The clinical, microbiological, and immunological effects of probiotic supplementation on prevention and treatment of periodontal diseases: A systematic review and meta-analysis. Microorganisms, 10(3), 592. https://doi.org/10.3390/microorganisms10030592
- Ram, J., et al. (2023). Clinical effects of Lactobacillus reuteri probiotic in chronic periodontitis – a systematic review. European Review for Medical and Pharmacological Sciences, 27(4), 1695–1707. https://doi.org/10.26355/eurrev_202302_31472
- Gasparro, R., et al. (2024). Effect of probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on caries and periodontal diseases: A systematic review. Dentistry Journal, 12(4), 102. https://doi.org/10.3390/dj12040102
- Messora, M. R., et al. (2016). Favourable effects of Bacillus subtilis and Bacillus licheniformis on experimental periodontitis in rats. Archives of Oral Biology, 66, 108–117. https://doi.org/10.1016/j.archoralbio.2016.02.019
- Tonetti, M. S., Jepsen, S., Jin, L., & Otomo-Corgel, J. (2017). Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action. Journal of Clinical Periodontology, 44(5), 456–462. https://doi.org/10.1111/jcpe.12732
- Luo, Y., et al. (2024). The impact of Lactobacillus reuteri on oral and systemic health: A comprehensive review of recent research. Microorganisms, 13(1), 45. https://doi.org/10.3390/microorganisms13010045
- Nicolaou, E., et al. (2024). Probiotics in the non-surgical treatment of periodontitis: a systematic review and network meta-analysis. BMC Oral Health, 24(1), 1209. https://doi.org/10.1186/s12903-024-05027-6
- Alanzi, A., Honkala, S., Honkala, E., Varghese, A., Tolvanen, M., & Söderling, E. (2018). Effect of Lactobacillus rhamnosus and Bifidobacterium lactis on gingival health, dental plaque, and periodontopathogens in adolescents: a randomised placebo-controlled clinical trial. Beneficial Microbes, 9(4), 593–602. https://doi.org/10.3920/BM2017.0139
- Gruner, D., Paris, S., & Schwendicke, F. (2016). Probiotics for managing caries and periodontitis: Systematic review and meta-analysis. Journal of Dentistry, 48, 16–25. https://doi.org/10.1016/j.jdent.2016.03.002
- Pudgar, P., et al. (2021). Probiotic strains of Lactobacillus brevis and Lactobacillus plantarum as adjunct to non-surgical periodontal therapy: 3-month results of a randomized controlled clinical trial. Clinical Oral Investigations, 25(3), 1411–1422. https://doi.org/10.1007/s00784-020-03449-4
- Soares, G. M. S., Carvalho, V. F., & Tinoco, E. M. B. (2019). Antimicrobial photodynamic therapy and probiotics for the treatment of chronic periodontitis in smokers: A randomized clinical trial. Photodiagnosis and Photodynamic Therapy, 27, 498–503. https://doi.org/10.1016/j.pdpdt.2019.07.003
- Tsubura, S., et al. (2009). The effect of Bacillus subtilis mouth rinsing in patients with periodontitis. European Journal of Clinical Microbiology & Infectious Diseases, 28(11), 1353–1356. https://doi.org/10.1007/s10096-009-0787-3
- Ratna Sudha, M., et al. (2020). Bacillus coagulans Unique IS-2 administration significantly reduced salivary mutans streptococci and Lactobacilli among high-risk dental caries children. Probiotics and Antimicrobial Proteins, 12(1), 56–62. https://doi.org/10.1007/s12602-018-9502-2
- Hatipoglu, H., et al. (2022). The use of probiotics as adjuvant therapy of periodontal treatment: A systematic review and meta-analysis of clinical trials. Pharmaceutics, 14(5), 1017. https://doi.org/10.3390/pharmaceutics14051017
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